RESET-BP
Trial question
What is the effect of sedentary behavior reduction on BP in desk workers?
Study design
Single center
Open label
RCT
Population
Characteristics of study participants
60.0% female
40.0% male
N = 271
271 patients (163 female, 108 male).
Inclusion criteria: adult desk workers with SBP 120-159 mmHg or DBP 80-99 mmHg, off antihypertensive medications, and reporting < 150 min/week of moderate-to-vigorous intensity physical activity.
Key exclusion criteria: SBP ≥ 160 mmHg or DBP ≥ 100 mmHg; receipt of antihypertensive or glucose-lowering medications; history of CVD; pregnancy; away from work desk for an extended period during follow-up.
Interventions
N=136 sedentary behavior reduction (behavioral strategies, environment modification, and proximal and distal external prompts to target a 2-4 hour/day reduction in sedentary behavior).
N=135 usual behavior (no intervention).
Primary outcome
Reduction in resting systolic blood pressure at 3 months
5.2 mmHg
4.6 mmHg
5.2 mmHg
3.9 mmHg
2.6 mmHg
1.3 mmHg
0.0 mmHg
Sedentary behavior
reduction
Usual
behavior
No significant
difference ↔
No significant difference in reduction in resting SBP at 3 months (5.2 mmHg vs. 4.6 mmHg; AD 0.22 mmHg, 95% CI -1.47 to 1.91).
Secondary outcomes
No significant difference in reduction in resting DBP at 3 months (3 mmHg vs. 3.2 mmHg; AD -0.13 mmHg, 95% CI -1.24 to 0.98).
No significant difference in reduction in 24-hour ambulatory SBP at 3 months (-0.2 mmHg vs. 0.1 mmHg; AD -0.31 mmHg, 95% CI -1.99 to 1.37).
No significant difference in elevation in carotid-femoral pulse wave velocity at 3 months (0.07 m/s vs. 0.01 m/s; AD 0.1 m/s, 95% CI -0.11 to 0.31).
Safety outcomes
No significant difference in adverse events.
Conclusion
In adult desk workers with SBP 120-159 mmHg or DBP 80-99 mmHg, off antihypertensive medications, and reporting < 150 min/week of moderate-to-vigorous intensity physical activity, sedentary behavior reduction was not superior to usual behavior with respect to reduction in resting SBP at 3 months.
Reference
Bethany Barone Gibbs, Subashan Perera, Kimberly A Huber et al. Effects of Sedentary Behavior Reduction on Blood Pressure in Desk Workers: Results From the RESET-BP Randomized Clinical Trial. Circulation. 2024 Oct 29;150(18):1416-1427.
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