CT-LIFE
Trial question
What is the role of preoperative cognitive training in patients undergoing CABG?
Study design
Multi-center
Single blinded
RCT
Population
Characteristics of study participants
31.0% female
69.0% male
N = 208
208 patients (64 female, 144 male).
Inclusion criteria: patients undergoing CABG.
Key exclusion criteria: life expectancy of < 6 months; psychiatric or neurological disorders; substantial impairments, such as blindness, severe deafness, or dementia that might hinder cognitive testing.
Interventions
N=102 cognitive training (substantial practice with a mobile application designed to enhance cognitive functions).
N=106 routine care (standard hospital attention without any specific cognitive training).
Primary outcome
Postoperative delirium
27.5%
43.4%
43.4 %
32.5 %
21.7 %
10.8 %
0.0 %
Cognitive
training
Routine
care
Significant
decrease ▼
NNT = 6
Significant decrease in postoperative delirium (27.5% vs. 43.4%; OR 0.42, 95% CI 0.23 to 0.77).
Secondary outcomes
Significant decrease in severe delirium (12.7% vs. 16%; OR 0.46, 95% CI 0.25 to 0.82).
No significant difference in median postoperative cognitive dysfunction score (56 points vs. 49 points; AD 7 points, 95% CI -3.91 to 17.91).
No significant difference in median number of days alive and out of hospital within 30 days (19 days vs. 20 days; AD -1 days, 95% CI -2.52 to 0.52).
Conclusion
In patients undergoing CABG, cognitive training was superior to routine care with respect to postoperative delirium.
Reference
Yu Jiang, Yanhu Xie, Panpan Fang et al. Cognitive Training for Reduction of Delirium in Patients Undergoing Cardiac Surgery: A Randomized Clinical Trial. JAMA Netw Open. 2024 Apr 1;7(4):e247361.
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