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The Five-Factor Score (FFS) calculator is a clinical tool used to assess the prognosis of patients with polyarteritis nodosa and eosinophilic granulomatosis with polyangiitis. The tool evaluates five clinical factors that relate to the severity and potential outcomes of these diseases. Each factor present in the patient adds one point to the overall score, facilitating a standardized assessment of risk.

Inputs required are:

- Proteinuria > 1 g/day
- Renal insufficiency with creatinine > 1.58 mg/dL
- Presence of cardiomyopathy
- Gastrointestinal (GI) bleeding, perforation, infarction, or pancreatitis
- Central nervous system (CNS) involvement

Each positive finding (i.e., each factor marked as true) is assigned a score of 1. The total FFS score is the sum of the points from the five inputs, resulting in a possible range from 0 to 5. This score correlates with specific prognostic interpretations regarding the 6-year mortality rate:

- A score of 0 suggests a 6-year mortality rate of 11.9%. This score indicates the absence of any major risk factors linked to the inputs, suggesting a relatively better prognosis.
- A score of 1 corresponds to a 6-year mortality rate of 25.9%. This modest increase in score from zero highlights the significance of even a single risk factor on long-term outcomes.
- Scores of 2 or more reflect a 6-year mortality rate of 45.95%, underscoring the compounding impact of multiple risk factors on the patient's prognosis.

By evaluating specific clinical parameters, this tool assists in risk stratification and helps guide management decisions for patients, highlighting the importance of addressing these key factors.

The calculator in question is the Five-Factor Score (FFS) for Polyarteritis Nodosa (PAN) and Eosinophilic Granulomatosis with Polyangiitis (EGPA). This scoring system is used in patients diagnosed with PAN and EGPA, two types of systemic vasculitis. The FFS is a prognostic tool that helps clinicians predict the five-year survival rate of these patients. It takes into account five factors: age over 65 years, cardiac symptoms, gastrointestinal involvement, renal insufficiency, and the absence of ear, nose, and throat symptoms. Each factor is assigned a score of 1, and the total score ranges from 0 to 2 (low risk) to 3 to 5 (high risk). The FFS is not applicable to patients with other types of vasculitis or those who have not been definitively diagnosed with PAN or EGPA.

FFS score for polyarteritis nodosa and eosinophilic granulomatosis with polyangiitis

The Revised Five Factor Score (rFFS) calculator is designed to assess the prognosis of systemic necrotizing vasculitis based on five clinical factors. Each input corresponds to a specific risk factor, which is quantified according to a predefined scoring system. The parameters include age over 65 years, renal insufficiency with a stabilized peak creatinine value of at least 150 micromoles per liter, cardiac insufficiency, gastrointestinal involvement, and absence of ear, nose, and throat (ENT) manifestations. 

The calculator assigns a score of 1 for each positive condition and a score of 0 for negative conditions, resulting in a total score ranging from 0 to 5. This cumulative score indicates the risk severity, with a higher score corresponding to a higher estimated 5-year mortality rate.

| Input Parameter                                                                 | Condition Met Value | Score Contribution |
|---------------------------------------------------------------------------------|---------------------|--------------------|
| Age > 65 years                                                                  | Yes                 | 1                  |
| Renal insufficiency stabilized peak creatinine >= 150 micromol/L                | Yes                 | 1                  |
| Cardiac insufficiency                                                           | Yes                 | 1                  |
| GI involvement                                                                  | Yes                 | 1                  |
| Absence of ENT manifestations                                                   | Yes                 | 1                  |

The scoring system evaluates each factor independently. The calculator then sums these values to produce a total score, which is interpreted as follows:

- A total score of 0 indicates a 5-year mortality rate of 9%.
- A total score of 1 indicates a 5-year mortality rate of 21%.
- A total score of 2 or more indicates a 5-year mortality rate of 40%.

In summary, the calculator assesses various risk factors to compute a score that projects a prognosis for patients with systemic necrotizing vasculitis. By doing so, it provides clinicians with valuable information for patient counseling and management strategies based on quantified risk levels.

The Revised Five Factor Score (rFFS) is a clinical calculator used for prognosis in patients with systemic necrotizing vasculitis. This scoring system is specifically designed for patients diagnosed with this rare autoimmune disease, which causes inflammation and damage to blood vessels throughout the body.

The rFFS is used to predict the likelihood of patient survival at five years following diagnosis. It takes into account five key factors: age over 65 years, cardiac symptoms, gastrointestinal involvement, renal insufficiency, and the absence of ear, nose, and throat symptoms. Each factor is assigned a score, and the total score is used to estimate prognosis.

The rFFS is not applicable to patients without a confirmed diagnosis of systemic necrotizing vasculitis. It also may not be as accurate in patients with other significant comorbidities or in those who have had the disease for a long time before diagnosis, as these factors can influence the course of the disease and the patient's overall prognosis.

Polyarteritis nodosa

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