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Non-ST-elevation myocardial infarction

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The American College of Cardiology (ACC) and American Heart Association (AHA) have updated their guidelines for the management of non-ST-elevation acute coronary syndromes (NSTE-ACS). A routine invasive approach is recommended for high- and intermediate-risk patients, while a routine or selective invasive approach is suggested for low-risk patients. Angiography before hospital discharge is suggested for non-high-risk patients intended for an invasive strategy. Upstream clopidogrel or ticagrelor is suggested for patients planned for an invasive strategy when angiography is expected to be delayed >24 hours, while ticagrelor is recommended for those managed without planned invasive evaluation. PCI of significant non-culprit lesions is recommended at the time of the index procedure or as a staged procedure in stable patients with multivessel disease but without left main stenosis undergoing culprit-lesion PCI. .

Guidelines

Key sources

The following summarized guidelines for the evaluation and management of non-ST-elevation myocardial infarction are prepared by our editorial team based on guidelines from the Society for Cardiovascular Angiography and Interventions (SCAI/NAEMSP/AHA/ACC/ACEP 2025), the American Academy of Family Physicians (AAFP 2024), the American College of Chest Physicians (ACCP 2024), the Canadian Cardiovascular Society (CCS/CAIC 2024), the European Society of Cardiology (ESC/EACTS ...
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