Table of contents
Expand All Topics
Neonatal respiratory distress syndrome
Guidelines
Key sources
The following summarized guidelines for the management of neonatal respiratory distress syndrome are prepared by our editorial team based on guidelines from the International Collaboration for Transfusion Medicine Guidelines (ICTMG 2024), the European Consensus Group on Respiratory Distress Syndrome (ECG-RDS 2023), the International Liaison Committee on Resuscitation (ILCOR 2022), the World Health Organization (WHO 2022,2015), the American Heart Association (AHA ...
Show more
Respiratory support
Oxygen targets: as per ECG-RDS 2023 guidelines, target saturation between 90-94% in preterm infants receiving oxygen beyond stabilization.
B
set alarm limits to 89% and 95%. B
More topics in this section
Noninvasive positive pressure ventilation
Invasive ventilation
Medical management
Setting of care: as per ECG-RDS 2023 guidelines, transfer pregnant females at high risk of preterm birth < 28-30 weeks of gestation to perinatal centers with experience in the management of respiratory distress syndrome.
B
More topics in this section
Initial stabilization
Hemodynamic control
Surfactant therapy (indications, respiratory distress syndrome)
Surfactant therapy (indications, secondary causes)
Surfactant therapy (choice of preparation)
Surfactant therapy (mode of administration)
Surfactant therapy (repeat doses)
Inhaled nitric oxide
Caffeine
Opioids
Antibiotic therapy
Management of patent ductus arteriosus
Nonpharmacologic interventions
Therapeutic procedures
RBC transfusion: as per ECG-RDS 2023 guidelines, consider using the following thresholds for RBC transfusion in infants:
12 g/dL (hematocrit 36%) in infants with severe cardiorespiratory disease
11 g/dL (hematocrit 30%) in oxygen-dependent infants
7 g/dL (hematocrit 25%) in stable infants beyond 2 weeks of age.
B
Specific circumstances
Patients with meconium aspiration syndrome, resuscitation: as per ACOG 2017 guidelines, do not perform intrapartum suctioning in infants with meconium-stained amniotic fluid, regardless of whether they are vigorous or not.
D
Show 2 more
More topics in this section
Patients with meconium aspiration syndrome (surfactant therapy)