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To determine if a patient meets the American Heart Association's diagnostic criteria for classic Kawasaki disease, this calculator evaluates six key symptoms. Each symptom has an associated score, and the sum of these scores determines the interpretation.

Here’s how the scoring works:

- Fever lasting five or more days is critical and scores 2 points.
- Changes in the lips or oral mucosa, such as erythema, cracking, or the appearance of a strawberry tongue, contribute 1 point.
- Bilateral bulbar conjunctivitis without exudate adds another 1 point.
- A rash, characterized as maculopapular, diffuse erythroderma, or erythema multiforme-like, also scores 1 point.
- Changes to extremities, including erythema and swelling of the hands and feet in the acute phase or periungual desquamation in the subacute phase, garner 1 point.
- Cervical lymphadenopathy, which is usually unilateral and at least 1.5 cm in diameter, scores 1 point.

By evaluating the boolean responses—whether these symptoms are present or not—the calculator assigns and sums the scores for a total that can range from 0 to 7.

Interpretation of the score is straightforward:
- A total score of 6 or more indicates that the diagnostic criteria for classic Kawasaki disease are met.
- A score of less than 6 means the criteria are not met.

This approach ensures a systematic assessment of symptoms associated with classic Kawasaki disease, providing a clear total score and interpretation based on standardized clinical criteria.

The American Heart Association (AHA) diagnostic criteria for classic Kawasaki disease is a clinical calculator used to diagnose Kawasaki disease, a condition that primarily affects children and involves inflammation of the blood vessels. This scoring system is specifically applicable to pediatric patients, typically under the age of 5, who present with prolonged fever and other clinical signs suggestive of the disease.

The AHA criteria for Kawasaki disease include five main clinical features: fever lasting 5 or more days, bilateral non-exudative conjunctivitis, changes in the lips and oral cavity, changes in the extremities, and polymorphous exanthem. The presence of cervical lymphadenopathy is also considered. 

The clinical utility of this calculator is to aid in the diagnosis of Kawasaki disease, which can be challenging due to its nonspecific symptoms and the lack of a definitive diagnostic test. Early diagnosis is crucial as the disease can lead to serious complications, such as coronary artery aneurysms, if not treated promptly.

Exclusion criteria for the use of this calculator include patients who do not meet the fever duration requirement or those who have an alternative diagnosis that better explains the clinical presentation. Additionally, it should be noted that a certain percentage of patients may have "incomplete" or "atypical" Kawasaki disease,

American Heart Association diagnostic criteria for classic Kawasaki disease (AHA criteria)

The Kobayashi score calculator is a tool used to predict the likelihood of a patient not responding to intravenous immunoglobulin (IVIG) therapy. It evaluates seven clinical factors to produce a total score that gives an interpretation about IVIG resistance. These are the criteria considered, and their scoring:

- Age of 12 months or less: 1 point
- Illness duration of 4 days or less at the time of initial treatment: 2 points
- Blood sodium levels of 133 mmol/L or less: 2 points
- Aspartate transaminase (AST) levels of 100 IU/L or more: 2 points
- Neutrophil levels of 80% or more: 2 points
- C-reactive protein levels of 10 mg/dL or more: 1 point
- Platelet count of 300,000/mcL or less: 1 point

Each factor that is true for the patient contributes its respective points to the total score. The score can range from 0 to 11. 

The interpretation of the score is straightforward:
- A score of 5 or higher suggests that the patient is likely to have IVIG-resistant disease. The probability is supported by sensitivity and specificity rates of 76% and 80%, highlighting its predictive reliability.
- A total score below 5 indicates that the likelihood of IVIG resistance is lower. The same sensitivity and specificity values also apply here, providing consistent metrics for understanding the patient's response to therapy.

Clinicians can use this score to better assess the risk of resistance to IVIG, aiding in more personalized and informed treatment decisions.

The Kobayashi score is a clinical calculator used in the pediatric population, specifically for children diagnosed with Kawasaki disease. Kawasaki disease is an acute febrile illness of unknown cause that primarily affects children younger than 5 years of age. The disease is characterized by inflammation in the walls of medium-sized arteries throughout the body, including the coronary arteries.

The Kobayashi score is used to predict the likelihood of a child with Kawasaki disease being unresponsive to initial intravenous immunoglobulin (IVIG) therapy. IVIG is a treatment commonly used in Kawasaki disease to reduce inflammation and prevent coronary artery abnormalities. However, some children do not respond to the initial IVIG treatment and require additional therapies.

The score is calculated based on several clinical and laboratory parameters including age, days of illness, platelet count, levels of aspartate aminotransferase, sodium, and C-reactive protein. A higher score indicates a higher risk of IVIG resistance.

The Kobayashi score is not applicable to patients who have already received IVIG therapy or those with incomplete or atypical Kawasaki disease. It is also not recommended for use in populations outside of Japan without appropriate validation, as the score was developed and validated in a Japanese population.

Kobayashi score for predicting unresponsiveness to IVIG therapy

The Egami score calculator predicts the likelihood of a patient being unresponsive to intravenous immunoglobulin (IVIG) therapy by evaluating five clinical factors. Each factor is input as a boolean, representing whether the condition is present. The total score, ranging from 0 to 6, offers an interpretation of the IVIG resistance likelihood.

Here's how the calculator works:

Inputs are provided on five clinical conditions:
- Age of 6 months or less
- 4 or fewer days of illness at the time of initial treatment
- Alanine aminotransferase (ALT) level of at least 80 IU/L
- C-reactive protein level of at least 8 mg/dL
- Platelet count of 300,000/mcL or lower

Each condition has a specific score weight, reflecting its significance in the Egami score:

| Condition                                                   | Score Weight |
|-------------------------------------------------------------|--------------|
| Age of 6 months or less                                     | 1            |
| 4 or fewer days of illness at initial treatment             | 1            |
| ALT level of at least 80 IU/L                               | 2            |
| C-reactive protein level of at least 8 mg/dL                | 1            |
| Platelet count of 300,000/mcL or lower                      | 1            |

To compute the score, the sum of the weights for all present conditions is calculated. This total score forms the Egami score, indicating the likelihood of IVIG resistance.

Interpretation of the score is straightforward:
- A score of 0 to 2 suggests a lower likelihood of IVIG resistance.
- A score of 3 or more implies that IVIG-resistant disease is likely, with the model having a sensitivity of 76% and a specificity of 80%. Essentially, this indicates a 76% probability that patients with a score of 3 or more are resistant to IVIG therapy, while an 80% probability exists that those scoring below 3 are not resistant.

The Egami Score is a clinical calculator used to predict the unresponsiveness to Intravenous Immunoglobulin (IVIG) therapy in patients with Kawasaki disease. Kawasaki disease is a rare childhood illness that affects the blood vessels and can lead to serious complications, such as heart disease. The Egami Score is particularly useful in identifying patients who are at high risk of being unresponsive to IVIG therapy, which is the standard treatment for Kawasaki disease. This allows clinicians to consider alternative or additional treatments early in the disease course. The score is calculated based on several factors including age, days of illness, platelet count, and levels of aspartate aminotransferase (AST) and sodium. The Egami Score is not applicable to patients without Kawasaki disease or those who have already started IVIG therapy.

Egami score for predicting unresponsiveness to IVIG therapy

The Sano score calculator is designed to predict the likelihood of unresponsiveness to IVIG (Intravenous Immunoglobulin) therapy based on three specific clinical criteria: AST levels, total bilirubin levels, and C-reactive protein levels. Each input corresponds to a binary factor indicating whether certain thresholds have been met:

1. AST (Aspartate Aminotransferase) level ≥ 200 IU/L
2. Total Bilirubin level ≥ 0.9 mg/dL
3. C-reactive Protein level ≥ 7 mg/dL

Each of these conditions contributes a score of 1 if true. The total score is calculated by summing the individual scores for these conditions. 

The computation uses this scoring method:
- A value of true for any of the three criteria indicates that the level is above the specified threshold, contributing 1 point to the score.
- The combined score ranges from 0 to 3, where each criterion met increases the score by 1.

The total score is used to provide an interpretation regarding the likelihood of resistance to IVIG therapy:
- A score of 2 or 3 suggests that the patient is likely to have IVIG-resistant disease, characterized by a sensitivity of 77% and specificity of 86%.

For clarity:

| Criteria                                  | Condition Met (True) | Score Contribution |
|-------------------------------------------|------------------------|---------------------|
| AST ≥ 200 IU/L                            | Yes                    | 1                   |
| Total Bilirubin ≥ 0.9 mg/dL               | Yes                    | 1                   |
| C-reactive Protein ≥ 7 mg/dL              | Yes                    | 1                   |

The final output consists of the computed score and its interpretation:

- If the score is 2 or more, it indicates a high probability of IVIG resistance, with the given sensitivity and specificity values.
- If the score is less than 2, no specific interpretation is provided by this calculator, indicating that the likelihood of resistance is lower based on the parameters considered.

The Sano score is a clinical calculator used to predict the unresponsiveness to Intravenous Immunoglobulin (IVIG) therapy in patients with Kawasaki disease. Kawasaki disease is a condition that primarily affects children and causes inflammation in the walls of medium-sized arteries throughout the body. The Sano score is particularly useful in identifying patients who are at high risk of being resistant to IVIG therapy, which is the standard treatment for Kawasaki disease. This allows for early intervention with additional or alternative treatments to prevent complications such as coronary artery aneurysms. The Sano score includes variables such as age, days of illness, platelet count, and levels of aspartate aminotransferase (AST), sodium, and C-reactive protein (CRP). It is not applicable to patients without Kawasaki disease or those who have already started IVIG therapy.

Kawasaki disease

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