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Fibromyalgia

Background

Overview

Definition
FM is a syndrome characterized by chronic widespread pain, fatigue, and sleep disruption.
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Pathophysiology
The exact cause of FM is unknown; however, central sensitization involving genetic, immunological, and hormonal factors have been implicated.
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Disease course
Clinical manifestations of FM include chronic widespread pain (diffuse, multifocal, deep, gnawing, burning, waxing and waning, and migratory), tender joints, fatigue, sleep disturbances, weight fluctuations, morning stiffness, irritable bowel disease, cognitive disturbance, depression, anxiety, headaches, heat and cold intolerance, irritable bladder syndrome, restless legs, and Raynaud's phenomenon.
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Prognosis and risk of recurrence
FM is not associated with increased mortality.
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Guidelines

Key sources

The following summarized guidelines for the evaluation and management of fibromyalgia are prepared by our editorial team based on guidelines from the American Academy of Family Physicians (AAFP 2023,2020), the Canadian Expert Group on Cannabinoids Use in Chronic Pain (CCP-CEG 2023), the Egyptian Consensus Group on Fibromyalgia (ECG-FM 2022), the Italian Society of Rheumatology (ISR 2021), the European League Against ...
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