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Chronic pancreatitis
What's new
Updated 2024 ASGE guidelines for endoscopic management in chronic pancreatitis .
Background
Overview
Definition
Chronic pancreatitis is a clinical syndrome involving inflammation, fibrosis, and loss of acinar and islet cells of the pancreas.
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Pathophysiology
The pathogenesis of chronic pancreatitis typically involves multiple risk modifiers that interact to produce pancreatic disease, including bile duct obstruction (pancreatic tumors, chronic strictures), exogenous toxins (alcohol, smoking), metabolic disturbances (hyperlipidemia, hypercalcemia), as well as autoimmune disease and genetic disease.
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Epidemiology
The incidence of chronic pancreatitis ranges from 5 to 12 cases per 100,000 person-years, while its prevalence is estimated at 50 persons per 100,000 population.
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Disease course
Destruction of normal pancreatic tissue leads to the clinical manifestations of chronic abdominal pain, exocrine insufficiency (compromised digestion, absorption, and metabolism of nutrients), and endocrine insufficiency (pancreatogenic diabetes).
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Prognosis and risk of recurrence
Patients with chronic pancreatitis have increased mortality as compared with age and sex-matched controls (HR 5.0, 95% CI 4.8-5.2).
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Guidelines
Key sources
The following summarized guidelines for the evaluation and management of chronic pancreatitis are prepared by our editorial team based on guidelines from the American Diabetes Association (ADA 2025), the American Society for Gastrointestinal Endoscopy (ASGE 2024), the American Gastroenterological Association (AGA 2023), the United European Gastroenterology (UEG/ESPEN 2023), the Japanese Society of Gastroenterology (JSG 2022), the American College of Gastroenterology ...
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