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Bulimia nervosa

Background

Overview

Definition
BN is an eating disorder characterized by recurrent episodes of binge eating followed by compensatory behaviors.
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Pathophysiology
The pathophysiology of BN is complex and not fully understood. It is thought to involve dysregulation of key neurotransmitters and neuropeptides in the brain, such as serotonin, which play a role in appetite regulation and mood.
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Epidemiology
The prevalence of BN in females in the US is estimated at 2-3%.
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Risk factors
Several risk factors are associated with BN, including genetic predisposition, psychological factors such as perfectionism and body dissatisfaction, as well as societal influences that emphasize thinness. Certain life stages, such as adolescence and early adulthood, may increase vulnerability to the disorder.
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Disease course
The clinical course of BN is marked by cycles of binge eating and compensatory behaviors, such as self-induced vomiting, laxative use, or excessive exercise, to prevent weight gain. These cycles can vary in frequency and intensity, and the disorder can be chronic, with periods of remission and relapse.
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Prognosis and risk of recurrence
The prognosis of BN varies. While many individuals can achieve recovery with appropriate treatment, others may experience a chronic course with ongoing symptom fluctuation.
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Guidelines

Key sources

The following summarized guidelines for the evaluation and management of bulimia nervosa are prepared by our editorial team based on guidelines from the American Psychiatric Association (APA 2023), the The Scottish Intercollegiate Guidelines Network (SIGN 2022), the U.S. Preventive Services Task Force (USPSTF 2022), the Canadian Practice Guidelines (CPG 2021,2020), the American Academy of Child and Adolescent Psychiatry (AACAP 2015), ...
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