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Alzheimer's disease

Background

Overview

Definition
Alzheimer's disease is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and functional impairment.
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Pathophysiology
Alzheimer's disease is characterized by two primary pathophysiological mechanisms: the accumulation of amyloid-beta plaques and the formation of neurofibrillary tangles. In addition, neuroinflammation, characterized by alterations in the functional responses of microglia and astrocytes and dysregulation of pro- and anti-inflammatory cytokines, also plays a significant role in the pathophysiology of Alzheimer's disease.
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Epidemiology
The prevalence of Alzheimer's disease worldwide is estimated at 598.97 per 100,000 population.
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Risk factors
Risk factors for Alzheimer's disease include advancing age, a family history of the disease, and a genetic predisposition, particularly the presence of the apolipoprotein E ε4 allele.
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Disease course
Clinically, Alzheimer's disease presents with progressive memory decline as well as cognitive deficits with executive dysfunction, language, visual perceptual difficulties, apraxia, and agnosia. Emotional and behavioral symptoms may also emerge in the moderate-to-severe stages of the disease.
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Prognosis and risk of recurrence
Alzheimer's disease is a chronic condition with no known cure. The prognosis is typically poor as the disease progressively worsens over time. The life expectancy following a diagnosis of Alzheimer's disease can vary between 3 to 10 years, with age being a significant predictor.
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Guidelines

Key sources

The following summarized guidelines for the evaluation and management of Alzheimer's disease are prepared by our editorial team based on guidelines from the American Academy of Family Physicians (AAFP 2024,2017,2011), the European Neurological Society (ENS/EAN/EFNS 2015), and the European Federation of Neurological Societies (EFNS 2010).
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