Sepsis-induced coagulopathy score (SIC score)

The Sepsis-induced Coagulopathy (SIC) score is a clinical calculator used in the management of patients with sepsis, a life-threatening condition caused by the body's response to an infection. The SIC score is specifically designed to identify patients with sepsis who have developed coagulopathy, a condition in which the blood's ability to clot is impaired. This can lead to an increased risk of bleeding or clotting complications. The SIC score is calculated using three parameters: platelet count, prothrombin time, and the Sequential Organ Failure Assessment (SOFA) score. A score of 4 or more indicates sepsis-induced coagulopathy. The clinical utility of the SIC score is to help guide therapeutic decisions, particularly the use of anticoagulant therapy, in patients with sepsis. It can also be used to stratify risk and predict outcomes in these patients. There are no specific exclusion criteria for the use of the SIC score, but it should be used with caution in patients with conditions that may independently affect coagulation, such as liver disease or anticoagulant therapy.

Reference

Toshiaki Iba, Marcello Di Nisio, Jerrold H Levy et al. New criteria for sepsis-induced coagulopathy (SIC) following the revised sepsis definition: a retrospective analysis of a nationwide survey. BMJ Open. 2017; 7(9): e017046.