The Dalteparin Dosage Calculator is designed to help determine the appropriate dosage of dalteparin for patients with varying medical needs. It takes into account three essential inputs: the patient's weight, kidney function measured through creatinine clearance, and the specific medical condition requiring treatment with dalteparin.

1. **Weight**: 
   - Patients can input their weight either in kilograms (kg) or pounds (lbs). If entered in pounds, the calculator automatically converts it to kilograms using the formula: weight in kg = weight in lbs / 2.20462. This ensures standardized calculations, accommodating weights from 2 to 500 kg or 4.4 to 1102 lbs.

2. **Creatinine Clearance (CrCl)**: 
   - This input is provided in milliliters per minute (mL/min), with a range from 10 to 150 mL/min. Creatinine clearance is pivotal in adjusting drug dosages, especially in patients with compromised renal function.

3. **Medical Indication**: 
   - Users select one of four indications: "DVT/PE treatment," "Cancer-associated thrombosis," "VTE prophylaxis in surgical patients," or "VTE prophylaxis in medical patients." The selected indication influences the recommended dosage pathway.

The dosage is determined as follows:

- For "DVT/PE treatment":
  - When creatinine clearance is below 30 mL/min, a dosage of "100 IU/kg twice daily" is recommended, with a note advising monitoring of anti-Xa levels due to necessary dose adjustments for those with severe renal impairment.
  - If creatinine clearance is 30 mL/min or more, the standard recommended dosage is "200 IU/kg once daily."

- For "Cancer-associated thrombosis":
  - The calculator prescribes a two-phase dosage: "200 IU/kg once daily" for the first month, followed by "150 IU/kg once daily," with a note about this dosage reduction.

- For "VTE prophylaxis in surgical patients" and "VTE prophylaxis in medical patients":
  - A standard dose of "5,000 IU once daily" is suggested. For surgical patients, the note indicates that it is best to start dosing 12 hours prior to surgery, while for medical patients, this dose is suited for those who are immobile.

An important consideration is the patient's renal function. If creatinine clearance is less than 20 mL/min, regardless of the medical indication, dalteparin is not recommended due to the potential risk of drug accumulation in severe renal impairment. The calculator then outputs a warning regarding this risk.

The outputs include the recommended dalteparin dosage and relevant notes, ensuring that each patient receives a dosage tailored to their specific medical profile while maintaining safety through appropriate precautions.

The Dalteparin Dosage Calculator is used to determine the appropriate dose of dalteparin, a low-molecular-weight heparin (LMWH), for prophylaxis or treatment of thromboembolic events. Dalteparin dosing depends on clinical indication, body weight, and renal function.

Dalteparin Dosage Calculator

Joint 2022 European Society of Thoracic Surgeons and The American Association for Thoracic Surgery guidelines for the prevention of cancer-associated venous thromboembolism in thoracic surgery.