The Clinical Prediction of Outcome in Malignant Pleural Effusion (PROMISE) score is a clinical calculator used in the management of patients with malignant pleural effusion (MPE). MPE is a condition often associated with advanced malignancies, where fluid accumulates in the pleural space surrounding the lungs.
The PROMISE score is used to predict the 3-month mortality rate in patients with MPE. It incorporates five clinical parameters: performance status, pleural fluid pH, serum albumin, serum lactate dehydrogenase, and serum neutrophil-to-lymphocyte ratio. Each parameter is assigned a score, and the total score is used to stratify patients into low, intermediate, and high-risk groups.
The clinical utility of the PROMISE score lies in its ability to guide clinical decision-making and patient counseling. It can help clinicians decide on the most appropriate management strategy for MPE, such as pleurodesis, indwelling pleural catheter placement, or conservative management.
The PROMISE score is not applicable to patients with non-malignant pleural effusions or those with incomplete clinical or laboratory data. It should also be used with caution in patients with multiple comorbidities or those receiving concurrent treatments that may affect
Reference
Ioannis Psallidas, Nikolaos I Kanellakis, Stephen Gerry et al. Development and validation of response markers to predict survival and pleurodesis success in patients with malignant pleural effusion (PROMISE): a multicohort analysis. Lancet Oncol. 2018 Jul;19(7):930-939.
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