Diagnostic criteria for syndrome of inappropriate antidiuretic hormone secretion
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Essential criteria
Effective serum osmolality < 275 mOsm/kg
Urine osmolality > 100 mOsm/kg
No clinical evidence of hypovolemia or hypervolemia
Urine sodium concentration > 30 mmol/L with normal dietary salt and water intake
Absence of adrenal, thyroid, pituitary or renal insufficiency
No recent use of diuretic agents
Supplemental criteria
Serum uric acid < 0.24 mmol/L [< 4 mg/dL]
Serum urea < 3.6 mmol/L [< 21.6 mg/dL]
Failure to correct hyponatremia after 0.9% saline infusion
Fractional sodium excretion > 0.5%
Fractional urea excretion > 55%
Fractional uric acid excretion > 12%
Correction of hyponatremia through fluid restriction
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